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TK Analytics at Swiss Biotech Day 2023
Our team is attending the Swiss Biotech Day 2023 conference, in Basel, Switzerland. At one of the leading biotech events in Europe we'll use the opportunity to connect with our European clients, while also following the latest advances in our...
CellPose vs. CellProfiler segmentation comparison
Image segmentation is an essential process and one of the first challenges in analyzing images of complicated cellular phenotypes at the single cell level. Accurate and efficient segmentation is crucial for extracting meaningful information from...
SLAS 2023: Ultra high-throughput drug discovery, organoids-on-chip and cell lines
Another SLAS 2023 conference wrapped up at the dawn of March in San Diego. It was packed with interesting talks, posters and exhibitors. Here we’ll showcase some of the most interesting talks, posters and products. The centre of the stage are of...
TK Analytics at SLAS2023 and Biocom Global Life Science Partnering & Investor Conference
The TK Analytics team is currently visiting the SLAS2023 Conference and Biocom Global Life Science Partnering & Investor Conference in San Diego, CA. We are always looking for opportunities to connect with our clients and discuss the latest...
Preprocessing Extracted Features
Preprocessing extracted features from cell painting images is an essential step in image-based profiling because it helps to ensure that the data is of high quality and is ready for further analysis. This can help to eliminate sources of error or...
High Content Screening platform: A Case Study
High content screening (HCS) is a powerful tool for understanding the effects of drugs, small molecules, and genetic manipulations on cells. The process involves imaging cells at high throughput and using software to analyze the images and extract...
Image Quality Control
The verification of image quality in high throughput experiments is virtually impossible to do by hand, that is why you can use automated methods to objectively label and remove images and cells that are affected by artifacts. These strategies aim...
Image Analysis
Image analysis is the process of converting digital information from images into measurements that characterize the status of each and every cell in an experiment. A digital image is basically a n-dimensional array of pixels, where each of the...
Polar Distribution Score
When looking at the microscopy images of ER exit sites we noticed that after a certain perturbation they change the distribution around the nuclei. ER exit sites in normal cells are more concentrated on one side. After the perturbation, the ER exit...
Mitochondria Structure & Measurement
The structure of mitochondria has been linked to disruptances in cellular processes, such as energy metabolism, calcium storage and lipid synthesis. Since mitochondria can be easily stained and imaged, it is also possible to measure their...
Cell Painting
The term “Cell painting” was first coined in 2016, by Bray et al., describing a morphological profiling assay to reveal eight broadly relevant cellular components or organelles by multiplexing six fluorescent dyes in five different channels. In...